What the research examined
A study of myostatin signaling investigated receptor binding and generated transgenic mice with altered expression of follistatin or other pathway components. The authors observed marked muscle-mass differences in those genetic models.
How to interpret the findings
Genetic overexpression is not equivalent to an experiment with a commercial compound. Muscle mass is also distinct from muscle function and overall health. The study establishes a biological relationship within its experimental design.
Research literature
- Regulation of myostatin activity and muscle growth.
Proceedings of the National Academy of Sciences of the United States of America · 2001 · PMID 11459935
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