What the research examined
MOTS-c research describes a mitochondrial-derived peptide involved in experimental metabolic signaling. Early work combined cellular experiments with mouse studies; later work examined movement into the nucleus during metabolic stress and associated gene-regulatory responses.
How to interpret the findings
These experiments investigate mechanisms. They do not establish a therapeutic effect in people, and measuring a naturally occurring peptide is different from testing an externally administered preparation.
Research literature
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.
Cell metabolism · 2015 · PMID 25738459 - The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress.
Cell metabolism · 2018 · PMID 29983246
Links open the indexed paper records. Summaries are based on those records and their available abstracts, not a systematic review or a full-text appraisal of every study.