What the research examined
A publication combined experiments on physical performance in mice with observations of endogenous MOTS-c in human muscle and circulation around exercise. The human and animal parts of the paper ask different questions.
How to interpret the findings
An exercise-associated change in a naturally occurring human peptide is not a trial of giving that peptide to people. The mouse intervention cannot fill that gap, and the two findings should not be presented as a demonstrated human performance effect.
Research literature
- MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.
Nature communications · 2021 · PMID 33473109
Links open the indexed paper records. Summaries are based on those records and their available abstracts, not a systematic review or a full-text appraisal of every study.